Videos from Genbank 25th Anniversary



Check out NCBI's Youtube channel, there are very interesting interviews taken on the eve of this event.

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Order, disorder, and phosphorylation

Phosphorylation selection. As protein kinases evolved and species complexity increased, the numbers of genomically encoded tyrosine residues [and thus phosphorylated tyrosines (pY)] decreased proportionally. This negative correlation also applies to threonine (pT) but not serine (pS) residues. Positionally conserved phosphorylation sites tend to be located in ordered protein domains, whereas those not conserved are located in intrinsically disordered regions where their exact positions shift with evolutionary time.

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How bioinfx geeks say happy birthday

echo QSVJRYHFCEXDILPKZTOBWA | grep -o . | sort -r | grep -v ‘[CKQW]‘ | perl -ne ‘chomp; print “$_\t”;’ | cut -f2,4- | perl -ane ‘$x=”KPFFAOJECKNPAIGMBMHBMCLPDD”; foreach $y (split(//,$x)) {print $F[ord($y)-65];} print “\n”;’

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